Robert Lustig – What is Metabolic Syndrome Anyway?

From the JumpstartMD Weight of the Nation Conference 2018

JumpstartMD is a medical practice dedicated to pre-emptive medicine through lifestyle changes and healthy, sustainable weight loss. Personalized program based on proven nutritional science, one-on-one lifestyle counseling and real, fresh food. Founded by Stanford trained physicians and board-certified Diplomates of the American Board of Obesity Medicine. PPO, HSA and FSA reimbursement support provided to patients.

With a strong commitment to reducing the quality and quantity of carbohydrates consumed, the stigmata of metabolic syndrome and fatty liver disease can reverse even before weight loss although much more dramatically in combination. For example, with as little as 10 percent weight loss, which 95 percent of our clients achieve at 6 months, NAFLD (Nonalcoholic fatty liver disease) is often reversed. Cost wise, patients without NAFLD show a 26 percent lowering in their health costs over 5 years.

But more importantly, with pre-emptive elimination of fatty liver disease, there’s no need to see the transplant surgeon. The prescription is simply guiding and supporting people toward healthy lifestyle changes that work to preempt diseases like fatty liver disease or the others that go along with it: diabetes, heart attacks, strokes, metabolic syndrome, various cancers, and arguably dementia. The improvements are dramatic, transformational, and utterly sensible.

JumpstartMD has convenient weight loss centers throughout the San Francisco Bay Area, from Marin to Monterey and San Francisco to Pleasanton. Our offices have a range of services and hours to help support your goals and lifestyle.

More at www.jumpstartmd.com or (855) JUMPSTART.
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Below are very safe supplements shown to improve insulin sensitivity
-Vitamin D
-Magnesium
-Chromium
-Cinnamon
-Apple cider vinegar
-Fish oil
-Tumeric
-Zinc
-Exercise/muscle contraction upregulates Glucose transporters in an insulin-independent fashion lowering blood glucose!

Personally, I believe excessive positive energy balance (obesity+sedentary), coupled with a genetic predisposition towards ectopic fat deposition and beta cell susceptibility for lipotoxicity, are major factors leading to insulin resistance.

VLDL — pancreas fat
Hypertrophic adipose tissue — lpl modification — higher residence time
Hypertrophic adipose tissue — Lipolysis — liver beta oxidation — Gluconeogensis
GWAS — susceptible to pancreas damage — T2D
Subcutaneous hypertrophy — macrophage release Lipolysis THF-alpha & IL-6 — Lipolysis — DAG in liver — PKC epsilon in liver

(PKC theta in muscle)

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This talk was given at a local TEDx event, produced independently of the TED Conferences. What can we learn from the physiology of endurance athletes as we tackle the epidemic of metabolic illnesses like diabetes and many other modern diseases? In this fascinating talk, Iñigo San Millán shows why endurance cyclists, runners and other athletes should be the gold standard in how we help people with different forms of metabolic dysfunction.

With more than 14 years of experience as an exercise physiologist and sports medicine adviser for many professional teams and elite athletes worldwide, Iñigo is considered one of the top and most experienced applied physiologists in the world. He has worked with many elite and world class athletes and teams in sports including track and field, running, cycling, triathlon, rowing and basketball, including six pro tour cycling teams, a Tour de France winner and 16 Grand Tours podium finishers.

About TEDx, x = independently organized event In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.* (*Subject to certain rules and regulations)
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We’re living in particularly stressful times, but keeping that stress in check is critical to overall health. A new study by researchers at The Ohio State University Wexner Medical Center and The Ohio State University College of Medicine finds this is especially important for those with Type 2 diabetes and documents a clear link between the stress hormone cortisol and blood sugar levels.

“In healthy people, cortisol fluctuates naturally throughout the day, spiking in the morning and falling at night,” said Dr. Joshua J. Joseph, an endocrinologist and researcher at The Ohio State Wexner Medical Center’s Diabetes and Metabolism Research Center who led the study. “But in participants with type 2 diabetes, cortisol profiles that were flatter throughout the day had higher glucose levels.”

These sustained levels of cortisol make it much more difficult to control blood sugar and manage the disease, which is why it’s so important for those with Type 2 diabetes to find ways to reduce stress. The study published online in the journal Psychoneuroendocrinology.

“We have begun a new trial to examine if mindfulness practices can lower blood sugar in those with Type 2 diabetes,” said Joseph. “But this isn’t the only effective form of stress relief. It’s important to find something you enjoy
and make it a part of your everyday routine.”

The relationship of cortisol with glucose levels was only observed in those with diabetes. However, Joseph and his team believe the stress hormone likely plays an important role in diabetes prevention and they continue to research the connection between cortisol and the development of diabetes and cardiovascular disease.

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Metabolic syndrome is a group of risk factors that raises risk of heart disease, diabetes, stroke, and other health problems and it make frequently serious and long-term complications.
What is metabolic syndrome, How metabolic syndrome be prevented and treated?

Today let’s talk about it.
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This animation helps the learner to understand the lipid abnormalities commonly seen in patients with type 2 diabetes. The animation focuses on the major role that elevated plasma free fatty acids (FFAs) play in the development of type 2 diabetes.
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Metabolic syndrome is a cluster of risk factors that can increase your risk of heart disease. Find out more about what these factors are and how you can prevent and manage this common yet potentially dangerous condition.

Presented by: Tyler D. Webster, MD, Cardiologist
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Sarah Hallberg is the Medical Director at Virta Health and a physician who has spent nearly two decades treating patients with obesity and type 2 diabetes. In the first half of this episode, Sarah discusses how she became a huge believer in the efficacy of carbohydrate restriction for the treatment of type 2 diabetes through her research and clinical experience. Sarah challenges the common beliefs about the role of dietary fat and carbohydrate on the plasma makeup of fatty acids and triglycerides. She also expresses the importance of understanding early predictors of metabolic illness—highlighting one particular fatty acid as the most important early predictor—before finishing with a discussion about how doctors might be able to personalize patients’ metabolic management in the future. In the second half of this episode, Sarah tells the personal story of her own lung cancer diagnosis. She talks about dealing with her grief, deciding to continue her work while prioritizing her family, and how she devised a plan to extend her survival as long as possible.

We discuss:
00:00:00 – Intro
00:00:10 – How Sarah discovered the profound impact of carbohydrate restriction for reversing obesity and type 2 diabetes
00:13:30 – Prediabetes and metabolic syndrome: prevalence, early signs, and the importance of treating early
00:27:45 – Overview of fatty acids, how they are metabolized, and understanding what you see in a standard blood panel
00:33:45 – The relationship between diet composition and metabolic markers
00:47:50 – Why palmitoleic acid is such an important biomarker
1:00:30 – The best early indicators of metabolic disease
1:07:45 – Personalized management of metabolic illness
1:16:50 – Sarah’s cancer diagnosis and the beginning of her journey
1:30:00 – The emotional impact of a devastating diagnosis
1:40:30 – Sarah’s plan to extend survival
1:52:15 – Sarah’s aggressive treatment plan
2:05:00 – Life-threatening complications and the return of her cancer
2:18:26 – Sarah’s reflections on her approach to life with chronic cancer and balancing her time

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The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 30 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.

Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).

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Professor Eran Segal of the Weizmann Institute speaks with Eric Topol, M.D. founder of the Scripps Research Translational Institute about how the gut microbiome intermediates metabolic diseases such as prediabetes and type 2 diabetes.
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#Metabolic #MetabolicSyndrome #metabolicHindi
METABOLIC SYNDROME क्या है ये ? || METABOLIC SYNDROME WHAT IS IT ? || विशेषज्ञ -डॉक्टर वी.के.मिश्रा (गैस्ट्रो एवं लिवर) || The Gastro Liver Hospital Kanpur || हॉस्पिटल में सम्पर्क करने के लिए या डॉक्टर से सलहा लेने के लिए इस नंबर पे बात करे :- 9956653103, 9793555775, 9793555776

Scientific facts with evidence
GASTRO LIVER HOSPITAL :- https://www.youtube.com/channel/UCgsBTy-UmF4OL-60iS5CK5w?view_as=subscriber

Dr. Vinod K.Mishra MBBS, MD, DM (Gastro) is a senior gastroenterologist , hepatologist, and endoscopist. He is an alumini of prestigious post graduate institute of medical education & research, (PGIMER) Chandigarh. He is a busy gastroenterologist performing about 1000 endoscopic procedures per month. He specializes in liver problems and all gastrointestinal diseases. He is trained in endoscopy, colonoscopy, ERCP, and endoscopic ultrasound.He has previously worked at All India Institute of Medical Sciences, New Delhi and Medical College, Jabalpur. He was President of UP chapter of Gastroenterology society.

The GASTRO LIVER HOSPITAL, where he works is a gastroenterology and hepatology super speciality hospital. Hospital has MEDICAL,and SURGICAL wings. It has ICU and plenty of accommodation facilities of different levels. The hospital performs all complicated and advanced surgeries under team of very senior and experienced gastro surgeon . All laparoscopic and open surgeries done .Advanced operations as whipple’s preocedure and oespophageal replacement s are done regularly not to mention of routine surgeries.This is possibily the only centre in north india doing cholecystectomy with intra operative ERCP on regular basis for Gall Bladder stone and CBD stones.The endoscopy unit has following facilities—-

• Endoscopy including multiband imaging.
• Colonoscopy
• ERCP
• Endoscopic ultrasound.
• Capsule endoscopy.
• Hydrogen breath test.
• Urea breath
• Fibroscan for liver diseases.

Currently he is working as
Dr. Vinod K. Mishra MD, DM (Gastro)
Chairman and Chief of Gastroenterology, Liver diseases and Endoscopy services at
The Gastro Liver Hospital
Swaroop Nagar Kanpur (UP), India

For online appointment or consultation
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Hyperglycemia or high blood sugar ,cause many of the warning signs of diabetes
• Slow-healing cuts and sores
• More hunger
• Peeing a lot
• Blurry vision
• Heavy thirst
. Fatigue
• Vaginal and skin infections
• Slow-healing cuts and sores
• Numb or tingling feet
Early Signs of Diabetes
Both types of diabetes have some of the same telltale warning signs.
. hunger and fatigue
•Peeing more often and being thirstier
.Dry mouth and itchy skin
.blurred vision
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#Metabolicsyndrome #Doctorq #MalayalamNews #KeralaLatestNews #News18

Metabolic syndrome is a cluster of conditions — increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels — that occur together, increasing your risk of heart disease, stroke and diabetes.

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In Peter Attia’s podcast The Drive Episode 194, he interviews Rick Johnson and they spend over two hours explaining how fructose causes metabolic disease: obesity, type 2 diabetes, etc. But it needs to be simplified and explained, and that’s what I do in this video!

Dr. Johnson’s hypothesis is that fructose is prime cause of metabolic syndrome and the rapid uptick of modern diseases. He writes about it in his new book “Nature Wants Us to Be Fat”. It explains a lot:

Why it’s harder to stay lean when we get older.
Why athletes seem like they can eat anything they want.
Why most traditional calorie restrictions diets are so hard to maintain
Why keto, low-carb, and paleo diets have had so much success

And importantly, his theory of fructose metabolism is still totally consistent with thermodynamics, and the equation “Calories in minus calories out equals weight gained” is still true.

Link to Podcast episode: https://youtu.be/V02z9mqTWzg
Amazon Affiliate link to Dr. Johnsons most recent book “Nature Wants Us to Be Fat”: https://amzn.to/3BmISvM
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Bariatric or weight loss surgery is considered a metabolic surgery. It does not only help patients lose weight but also helps to resolve other metabolic conditions such as type 2 diabetes, high blood pressure and sleep apnea.
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