Presented by Dr Dorit Samocha-Bonet From Garvan’s Type 1 and Type 2 Diabetes Seminar: http://www.garvan.org.au/get-involved/events. Dr Samocha-Bonet discusses the changes in dietary recommendations over the years, the alkalising diet and gives her tips on healthy eating.
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Robert H. Lustig, M.D., M.S.L. is Professor emeritus of Pediatrics, Division of Endocrinology at the University of California, San Francisco (UCSF). He specialises in the field of neuroendocrinology, with an emphasis on the regulation of energy balance by the central nervous system. His research and clinical practice has focused on childhood obesity and diabetes. Dr. Lustig holds a Bachelor’s in Science from MIT, a Doctorate in Medicine from Cornell University. Medical College, and a Master’s of Studies in Law from U.C. Hastings College of the Law.
Dr. Lustig has fostered a global discussion of metabolic health and nutrition, exposing some of the leading myths that underlie the current pandemic of diet-related disease. He believes the food business, by pushing processed food loaded with sugar, has hacked our bodies and minds to pursue pleasure instead of happiness; fostering today’s epidemics of addiction and depression. Yet by focusing on real food, we can beat the odds against sugar, processed food, obesity, and disease.
Please consider supporting Low Carb Down Under via Patreon. A small monthly contribution will assist in the costs of filming and editing these presentations and will allow us to keep producing high quality content free from advertising. For further information visit; https://www.patreon.com/lowcarbdownunder
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View episode show notes here: https://bit.ly/3ugel18
Rick Johnson, Professor of Nephrology at the University of Colorado and a previous guest on The Drive, returns for a follow-up about unique features of fructose metabolism, and how this system that aided the survival of human ancestors has become potentially hazardous based on our culture’s dietary norms. In this episode, Rick explains how the body can generate fructose from glucose and how circulating glucose and salt levels can activate this conversion. He discusses the decline in metabolic flexibility associated with aging, as well as how factors such as sugar intake or menopause-associated hormone changes can alter responses to sugar across a lifetime. In addition, Rick lays out strategies for combating the development of metabolic illness using dietary changes and pharmaceutical therapies, and he discusses the impact of fructose metabolism and uric acid on kidney function and blood pressure. He concludes with a discussion of vasopressin, a hormone that facilitates fructose’s effects on weight gain and insulin resistance.
We discuss:
00:00:00 – Intro
00:00:10 – Unique features of fructose metabolism and why it matters
00:09:00 – A primer on fructose metabolism and uric acid
00:21:04 – Endogenous fructose production, the polyol pathway, and the effect of non-fructose sugars
00:28:20 – Findings from animal studies of glucose and fructose consumption
00:45:06 – What calorie-controlled studies say about the claim that a “calorie is a calorie”
00:56:45 – Implications for aging and disease
01:08:58 – Impact of endogenous fructose production on obesity and metabolic syndrome
01:12:43 – Why vulnerability to the negative effects of sugar increases with age and menopause
01:26:43 – Dietary strategies to reduce the negative impact of fructose
01:43:56 – The role of hypertension in chronic disease and tips for lowering blood pressure
01:54:16 – The impact of fructose and uric acid on kidney function and blood pressure
02:04:50 – The potential role of sodium in hypertension, obesity, and metabolic syndrome
02:11:18 – The role of vasopressin in metabolic disease
——–
About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 35 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.
Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).
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#DiabetesMellitus,#Diabetes,#HighlevelSugar,#diabetes,#diabetesmellitus,#diabetestreatment,
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Diabetes mellitus, or diabetes,
is a metabolic disease that causes
high blood sugar levels.
Insulin transports sugar from the
blood into your cells, where it is
stored or used for energy. Diabetes
occurs when your body either does
not produce enough insulin or does
not use the insulin that it does
produce effectively.
Diabetes-related high blood sugar
can harm your nerves, eyes, kidneys,
and other organs if left untreated.
Diabetes is classified into several
types:Diabetes type 1 is an autoimmune
disorder.
The immune system attacks
and destroys cells in the
pancreas, which manufactures
insulin.
It is unknown what is causing
this attack.
This type affects
approximately 10% of diabetics.
Type 2 diabetes develops
when your body becomes
resistant to insulin,
causing sugar to accumulate
in your blood.
Prediabetes is defined
as having blood sugar
levels that are higher
than normal but not high
enough to warrant a
diagnosis of type
2 diabetes.
Gestational diabetes is
defined as high blood sugar
levels during pregnancy.
Insulin-blocking hormones
produced by the placenta
cause this type of diabetes.
A rare condition called
diabetes insipidus is not
related to diabetes mellitus,
although it has a similar name.
It’s a different condition
in which your kidneys remove
too much fluid from your body.
Symptoms of diabetes
Diabetes symptoms are
caused by rising blood
sugar.
General symptoms
The general symptoms
of diabetes include:
*Increased hunger
*Increased thirst
*Weight loss
*Frequent urination
*Blurry vision
*Extreme fatigue
*Sores that don’t heal
Symptoms in men
In addition to the general
symptoms of diabetes, men
with diabetes may have a
decreased sex drive,
erectile dysfunction
(ED), and poor muscle
strength.
Symptoms in women
Women with diabetes can also
have symptoms such as urinary
tract infections, yeast
infections, and dry,
itchy skin.
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Definition, diagnosis, risk factors, treatments. This video is available for instant download licensing here: https://www.alilamedicalmedia.com/-/galleries/images-videos-by-medical-specialties/metabolism/-/medias/ecf4765f-4f5d-41f0-ae11-54d1827ebf82-metabolic-syndrome-narrated-animation
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Metabolic syndrome, also called syndrome X or insulin resistance syndrome, refers to a combination of metabolic risk factors that increase the chance of developing cardiovascular diseases, such as heart attacks or strokes; and type 2 diabetes.
Metabolic syndrome is diagnosed when a patient has at least three of the following:
– A waistline of 40 inches or more for men, or 35 inches or more for women;
– A systolic blood pressure above 130 and a diastolic blood pressure above 85 mmHg, or if the patient is taking blood pressure-lowering medications;
– A fasting blood sugar level above 100 mg/dL, or if the patient is taking glucose-lowering medications;
– A triglyceride level greater than 150 mg/dL;
– An HDL level of less than 40 mg/dL for men, or 50 mg/dLfor women.
Metabolic syndrome, in turn, has its own set of underlying risk factors, of which insulin resistance is most important. Insulin resistance is when the body’s cells do not respond well to insulin and therefore cannot use glucose; glucose stays in the blood, causing high blood sugar levels while the cells are deprived of nutrition. Insulin resistance can be acquired, hereditary, or mixed. Other risk factors include abdominal obesity, physical inactivity, aging, hormonal imbalances, and use of certain medications. Women are more susceptible than men. Some racial and ethnic groups are at higher risk than others.
Metabolic syndrome is often associated with excessive blood clotting and chronic low-grade inflammation, as well as several other conditions, but the cause-effect relationship is not clear.
The goal of treating metabolic syndrome is to reduce the risk of cardiovascular diseases. Treatment aims to lower blood pressure and cholesterol; and to manage diabetes, or prevent it, if it hasn’t already developed.
Lifestyle changes include a heart-healthy diet, physical activity plan, weight management, stress management, and quitting smoking.
If lifestyle changes aren’t enough, medications may be prescribed to lower LDL cholesterol and triglycerides; to reduce blood pressure, blood sugar level, or to prevent blood clots.
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Diabetes mellitus is a group of metabolic diseases that causes a person to have high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. It’s also a disease of the immune system.
Diabetes affects about 8 percent of the U.S. population or 25 million people. 285 million worldwide. It is estimated that half of all Americans will have diabetes by 2020.
High blood sugar produces the classical signs and symptoms of diabetes: thirst, hunger, weight loss, frequent urination…
Type 2 diabetes is a consequence of a seismic shift in lifestyle beginning about ten thousand years ago.
The shift was from hunting and gathering food to farming and raising animals, then eating the fruit of that labor. Before the shift, Neolithic hunter gatherers gorged food to store body fat in good times to ward off starvation in lean times. Body fat was life insurance!
Today, gobbling food in excess has developed into a pathology linked to obesity, type 2 diabetes, heart disease, and stroke. .
Type 1 Diabetes results from autoimmune destruction of insulin producing beta cells of the pancreas. Incidence varies from eight to 17 per 100 thousand in the U.S. It is fatal unless treated with insulin.
.
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