Dr. Darien Sutton discusses the new stem cell treatment and pharmaceutical trial that allows Brian Shelton’s body to control its own insulin and blood sugar levels.

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Insulin shots and organ transplants for Type I Diabetes and Type II Diabetes could become a thing of the past with Seraxis, and patients dependent on glucose may go free.

To learn more about the Maryland Stem Cell Research Fund (MSCRF), visit www.mscrf.org
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The two types of diabetes, Type I Diabetes & Type II Diabetes, affect 1 in every 10 Americans. Type I remains the leading cause of a host of issues, including blindness, cardiovascular disease, kidney disease, liver failure, and limb amputation, and it can remove up to 10 years from someone’s life expectancy.

While a pancreas transplant is curative for this devastating disease, there is no mass therapy or cure, and there aren’t enough transplants for everyone.

However, as Seraxis founder Dr. William Rust explains in this video, the entire organ doesn’t need to be transplanted to have the same curative impact. Scientists have discovered that only the small clusters of Pancreas “islet” cells, responsible for secreting insulin, need to be transplanted to provide a cure.

Dr. Rust knows “the race is on to develop a supply of islets that does not come from organ donation so that all of the patients who need this therapy can have it.” Seraxis developed a cell therapy made up of lab-grown islets cells that are functional, curative, and don’t require immune suppression.

Seraxis’s research is leading the charge, and because of funding from the Maryland Stem Cell Research Fund, its preliminary findings showed exciting promise and it’s on the verge of launching its first clinical trial to show its efficacy in humans. If all goes successfully, they believe they’ll be able to commercialize this cellular therapy for patients in need in the next 5 years.

“We hope to demonstrate that patients, who previously needed injections 5 times a day, can walk out of the clinic completely independent of insulin,” shares Dr. Rust.

Despite the dire need of developing a cure for diabetes that is independent of an organ transplant, Dr. Rust explains “there is very little support for doing this type of work,” with the exception of the support he received from the Maryland Stem Cell Research Fund. For details about the Fund’s support of Seraxis, visit: https://www.mscrf.org/portfolio-companies/seraxis-inc

The Fund has been true to its mission of accelerating cures by supporting the market leader in cell therapy development for Diabetes. To learn more about the Maryland Stem Cell Research Fund, visit: www.mscrf.org

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Apply now: https://www.mscrf.org/funding-opportunities

Interested in collaborating with us? Reach out to Dr. Amritha Jaishankar, Executive Director, MSCRF: http://www.linkedin.com/in/amrithajaishankar

Or, follow us on LinkedIn or Twitter to learn about opportunities:
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Disclaimer: MSCRF does not endorse the comments on our videos – please do not take comments from our audience as medical advice. Visit www.clinicaltrials.gov to learn about ongoing clinical research studies and please consult your physician to evaluate your condition and treatment options.

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A diabetes diagnosis means the body cannot regulate blood sugar due to inadequate insulin production from the pancreas — a long, flat gland that sits behind the stomach in the upper abdomen. The results for a patient with diabetes can be vision loss, and nerve and damage to other organs, unless blood sugar is controlled using medication or the patient undergoes a pancreas transplant.

“A pancreas transplant is the only cure for diabetes. It does not control diabetes. It cures diabetes,” says Dr. Tambi Jarmi, a transplantation medicine physician at Mayo Clinic. “I find myself having a hard time convincing a diabetic patient after they receive the pancreas transplant that they are cured ― they’re not diabetic. They don’t believe it.”
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Dr. Bob explains the common symptoms of diabetes.
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When a person gets his blood sugar checked and finds that there is an increase in the blood sugar levels, immediately they are advised medications. This medication infect is to bring down the blood sugar level and is not to treat the diabetes as a whole because what we see is inspite blood sugar levels remaining low, people suffer from complications like diabetic neuropathy congestive cardiac issues kidney failure, blindness etc. we are talking about type 2 diabetes. Why does this happen? This is because the medication masks the condition by bringing down the blood sugar levels. In Ayurveda the diabetes is correlated to madhumeha where all the three doshas, the vata, pitta and kapha are in imbalance. There is no single mode of management. It is complete lifestyle change because what we see it is a resultant of a long period of a faulty lifestyle. So it takes equal amount of time to get it reversed. There are basic methods to reverse diabetes especially among youngsters because they are the maximum ones suffering because of faulty lifestyle and becoming obese or overweight. The first method is to control the diet. What people do is take off carbohydrate, instead take out refined carbohydrates and incorporate fruits and vegetables that are rich in vitamins and minerals and along with unrefined carbohydrates like the whole grain because this is rich in fibre that is essential. The next is exercise to reduce your body weight because obesity to reduce body weight. Here obesity is one of the primary reasons to become diabetic. Exposure to early morning sunlight is essential to fight diabetes. Do not sleep during the daytime. The next factor is stress. Yoga and meditation keeps the mind calm and keeps the complication of diabetes due to stress. The other factor is to incorporate certain spices in the diet like turmeric, fenugreek, cinnamon fights the insulin resistance from the body. These helps in reversing diabetes. But in some cases the toxic build-up is so much that in spite of following all this their blood sugar does not come down. In such conditions the detoxification programme of Ayurveda, what we call as the panchkarma treatment is essential to get off the toxicity and follow healthy lifestyle. With this there can be lot of changes, in paediabetic people it is seen to reverse diabetic status. In diabetic we can avoid complication and improve the quality of life.

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Did you know that over 450 million people around the world currently have diabetes? Diabetes is an often debilitating condition that is the second-leading cause of amputation and the number-one cause of blindness among adults.

But we may be close to curing diabetes with the help of a printed pancreas. The new technology is the future of lab-grown organs for the replacement of body parts, and it’s surprisingly advanced.

Readily3D, a spin-off of EPFL, developed a new method to print biological tissues using a biological gel that contains the patient’s stem cells. A laser is used to harden the gel by polymerization, and the laser beam’s position and intensity may be adjusted to harden the portions of gel required to make the appropriate tissue.

Impressively enough, the method takes just 30 seconds for living tissue to be printed out on a bioprinter complete with blood vessels and all. This has never been done before and could revolutionize how we produce replacement organs.

The printed pancreas secretes a spectrum of critical hormones like insulin, which help regulate blood sugar levels. From now on, diabetes could soon be treated by creating a bio-printed pancreas to exactly match the patient’s deficient one.

This could eliminate the need to put patients on drugs that often have nefarious side effects and also get rid of animal testing. The solution is a win-win for all.

Moreover, the technology could also one day be used to build all kinds of other organs.

Find out more information at https://bit.ly/3gYuaRS

#engineering
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In a story first reported by The New York Times, a revolutionary cell transplant helped restore one man’s natural ability to create and regulate insulin, offering him a potential new lease on life.
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Reversing Diabetes – Dr.Ravi Sankar Endocrinologist MRCP(UK) CCT – GIM (UK)

Reversing diabetes is a term that usually refers to a significant long-term improvement in insulin sensitivity in people with type 2 diabetes.

People with type 2 diabetes that are able to get their HbA1c below 42 mmol/mol (6%) without taking diabetes medication are said to have reversed or resolved their diabetes. This also known as putting diabetes into remission.

Loss of body weight can be particularly beneficial in helping to reverse the progression of diabetes.

With time and dedication, type 2 diabetes can be reversed and the results can be very rewarding, with less tiredness and better all-round health.

If you think you need to come off your diabetes medication, ensure you speak to your healthcare team before doing so.

Understanding how diabetes progresses
The most common cause of type 2 diabetes is obesity-related, which generally follows a vicious cycle pattern:

Diet high in calories -particularly if high in refined carbohydrates.
Insulin levels in the bloodstream rise to cope with the high- and quick-acting carb intake.
Weight is gained around the belly (central or truncal obesity).
Consistently high insulin levels lead to the body’s cells becoming resistant to insulin and commonly lead to weight gain.
High insulin levels also increase weight gain.
Insulin resistance leads to an increase in blood sugar levels, particularly after meals.
The pancreas produces more insulin to cope with rising blood sugar levels
High sugar levels lead to feelings of lethargy and high insulin levels lead to increased hunger.
Hunger often leads to overeating and lethargy, with less physical activity being taken.
Overeating, less activity and high insulin levels all lead to further weight gain and more insulin resistance.
Consistently high demand on the pancreas to produce extra insulin leads to damage of the pancreas’ insulin-producing beta cells.
Beta cell damage results in the body struggling to produce enough insulin, and steeper rises in blood sugar levels leads to more recognisable symptoms of diabetes, symptoms of diabetes, such as thirst and a frequent need to urinate

#diabetes #reversingdiabetes #reversetype1diabetes #reversetype2diabetes #endocrinology #clinicalessentials #usmle
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An implantable, bioartificial pancreas at the University of Arizona Health Sciences may soon provide a new treatment option for adults and children with Type 1 diabetes.

For the approximately 1.6 million people who live with Type 1 diabetes, insulin is a lifeline. Without it, the body can go into shock, resulting in organ damage, swelling in the brain and even death. Currently, the only way for a person with Type 1 diabetes to get this life-saving insulin is by regularly measuring their blood sugar levels with a self-administered blood test and then giving themselves necessary injections, or by using an insulin pump, an external device that delivers insulin as needed through a tube placed under the skin.

A UArizona Health Sciences research team led by Klearchos Papas, PhD, a professor at the UArizona College of Medicine – Tucson, is closing in on a better solution. Dr. Papas is developing a tiny implantable device that mimics the normal function of the pancreas, the organ responsible for insulin production.

Dr. Papas’ solution comes in the form of an oxygen-enabled implantable pouch packed with islets that are separated and protected from the body’s immune system. The device differs from an insulin pump in that it will closely mimic a normal pancreas and offer more durable, timely and accurate glucose sensing and insulin.

“The beauty of our approach is that instead of having to inject yourself with insulin, you have cells producing it on demand and releasing it as needed,” said Dr. Papas. “You essentially replace the physiological function of insulin production as close to what you had with your original pancreas.”
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The first symptoms of diabetes may seem insignificant when in truth they are not. This video describes 8 warning signs you should never ignore. You can also find out more about diabetes and how to manage the condition at HealthExpress: https://bit.ly/3x9spuG

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