What are the early warning signs of diabetes?

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What are the symptoms of diabetes? With one in 15 of us now living with condition in the UK, it’s more important than ever to know the signs and symptoms to look out for.

We hope you enjoy this short animation to raise awareness and get more people talking about the signs and symptoms of type 1 and type 2 diabetes.

Common symptoms of diabetes include:

– Going to the toilet a lot, especially at night.
– Being really thirsty.
– Feeling more tired than usual.
– Losing weight without trying to.
– Genital itching or thrush.
– Cuts and wounds take longer to heal.
– Blurred eyesight.

For more information, go to our website: https://www.diabetes.org.uk/diabetes-the-basics/diabetes-symptoms

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We are Diabetes UK. Our vision is a world where diabetes can do no harm.

We’re leading the fight against the UK’s biggest and growing health crisis. And it’s a fight that involves us all – sharing knowledge and taking on diabetes together.

Type 2 Diabetes Signs & Symptoms (& Why They Occur)

Type 2 diabetes is a condition involving impaired glucose regulation, which is caused by impaired insulin sensitivity, decreased glucose tolerance and increased glucose levels. Increased glucose levels can cause a variety of signs and symptoms as it affects multiple organ systems. In this lesson, we discuss all of these signs and symptoms, including associated conditions, and why they occur in Type 2 Diabetes.

I hope you find this lesson helpful. If you do, please like and subscribe for more lessons like this one!

JJ

**MEDICAL LEGAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal. Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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Over the past 20 years, significant advancements in stem cell research and therapies have been one of the most promising methods of creating new insulin making cells needed to cure type 1 diabetes.

Vertex Pharmaceuticals, a biotech company, recently began a clinical trial where it plans to treat 17 participants who have type 1 diabetes with new stem cell derived insulin making cells. The first patient in the trial has had positive results.

Other companies around the world including ViaCyte and CRISPR, as well as Novo Nordisk, one of the biggest insulin manufacturers in the world, are also working on curing the disease. CNBC explores why finding a cure for diabetes is so hard and just how close Vertex and other companies are to solving this problem.

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How There Could Finally Be A Cure For Diabetes

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Definition, diagnosis, risk factors, treatments. This video is available for instant download licensing here: https://www.alilamedicalmedia.com/-/galleries/images-videos-by-medical-specialties/metabolism/-/medias/ecf4765f-4f5d-41f0-ae11-54d1827ebf82-metabolic-syndrome-narrated-animation
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Voice by : Marty Henne
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All images/videos by Alila Medical Media are for information purposes ONLY and are NOT intended to replace professional medical advice, diagnosis or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition.
Metabolic syndrome, also called syndrome X or insulin resistance syndrome, refers to a combination of metabolic risk factors that increase the chance of developing cardiovascular diseases, such as heart attacks or strokes; and type 2 diabetes.
Metabolic syndrome is diagnosed when a patient has at least three of the following:
– A waistline of 40 inches or more for men, or 35 inches or more for women;
– A systolic blood pressure above 130 and a diastolic blood pressure above 85 mmHg, or if the patient is taking blood pressure-lowering medications;
– A fasting blood sugar level above 100 mg/dL, or if the patient is taking glucose-lowering medications;
– A triglyceride level greater than 150 mg/dL;
– An HDL level of less than 40 mg/dL for men, or 50 mg/dLfor women.
Metabolic syndrome, in turn, has its own set of underlying risk factors, of which insulin resistance is most important. Insulin resistance is when the body’s cells do not respond well to insulin and therefore cannot use glucose; glucose stays in the blood, causing high blood sugar levels while the cells are deprived of nutrition. Insulin resistance can be acquired, hereditary, or mixed. Other risk factors include abdominal obesity, physical inactivity, aging, hormonal imbalances, and use of certain medications. Women are more susceptible than men. Some racial and ethnic groups are at higher risk than others.
Metabolic syndrome is often associated with excessive blood clotting and chronic low-grade inflammation, as well as several other conditions, but the cause-effect relationship is not clear.
The goal of treating metabolic syndrome is to reduce the risk of cardiovascular diseases. Treatment aims to lower blood pressure and cholesterol; and to manage diabetes, or prevent it, if it hasn’t already developed.
Lifestyle changes include a heart-healthy diet, physical activity plan, weight management, stress management, and quitting smoking.
If lifestyle changes aren’t enough, medications may be prescribed to lower LDL cholesterol and triglycerides; to reduce blood pressure, blood sugar level, or to prevent blood clots.
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Diabetes mellitus is a group of metabolic diseases that causes a person to have high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. It’s also a disease of the immune system.

Diabetes affects about 8 percent of the U.S. population or 25 million people. 285 million worldwide. It is estimated that half of all Americans will have diabetes by 2020.

High blood sugar produces the classical signs and symptoms of diabetes: thirst, hunger, weight loss, frequent urination…
Type 2 diabetes is a consequence of a seismic shift in lifestyle beginning about ten thousand years ago.

The shift was from hunting and gathering food to farming and raising animals, then eating the fruit of that labor. Before the shift, Neolithic hunter gatherers gorged food to store body fat in good times to ward off starvation in lean times. Body fat was life insurance!

Today, gobbling food in excess has developed into a pathology linked to obesity, type 2 diabetes, heart disease, and stroke. .
Type 1 Diabetes results from autoimmune destruction of insulin producing beta cells of the pancreas. Incidence varies from eight to 17 per 100 thousand in the U.S. It is fatal unless treated with insulin.
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medskl.com is a global, free open access medical education (FOAMEd) project covering the fundamentals of clinical medicine with animations, lectures and concise summaries. medskl.com is working with over 170 award-winning medical school professors to provide content in 200+ clinical presentations for use in the classroom and for physician CME.

Endocrinology – Diabetes Mellitus
Whiteboard Animation Transcript
with Dawn Dewitt, MD
https://medskl.com/Module/Index/diabetes-mellitus

Hypoglycemia, or low blood sugars, is the most common, and one of the most feared, complication of diabetes treatment. It must be taken seriously as patients can die from this condition. Having an episode raises the risk of mortality over the next 12 months by 65%.

Hypoglycemia is often triggered when those with uncontrolled diabetes try to achieve “tight control”. You must think of hypoglycemia in a diabetic patient who presents with signs and symptoms of epinephrine release, like shakiness, anxiety, tremor, palpitations and sweating.

Usually patients with neuroglycopenia, or low brain blood sugar, have confusion, seizures and coma.

Severe hypoglycemia is defined as needing the help of another person.

If a patient with diabetes presents with signs suggestive of hypoglycemia… remember the following:

Consider hypoglycemia even with “normal” sugar levels in a patient with uncontrolled diabetes. Their glucose may be falling rapidly with better control
You need to rule out mimicking conditions like acute myocardial ischemia or infection
If patients need beta blockers for heart problems, counsel them that beta-blockers do not usually eliminate the symptoms of hypoglycemia; most patients on beta-blockers still have profuse “sweats” as a symptom of hypoglycemia

Causes of hypoglycemia include:

too much insulin or sulfonylurea
mismatch of insulin, sulfonylurea or exercise with food intake
continuing to take diabetes medications with nausea, vomiting or diarrhea
decreased renal clearance of insulin or sulfonylureas

Most patients with mild or moderate hypoglycemia can self-treat with oral glucose like jelly-beans, but hospitalization may be required for severe hypoglycemia.

Remember to continue “basal” insulin in patients with T1DM!  They require insulin and will go into DKA because they REQUIRE some insulin at all times. Give intravenous glucose as needed. 

The key to lowering the risk of further episodes of hypoglycemia includes a detailed understanding the timing of the patient’s medications insulin (onset, peak and duration) with respect to when they eat and exercise. Frequent blood sugar monitoring is critical.
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Link to a pdf with question and answers based on the video:
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Tratamiento de la diabetes mellitus: una introducción.

NUEVO VÍDEO AQUÍ ► https://www.youtube.com/watch?v=NUYtHLBV6S0&list=UU9ohLcxGUDGVIp69s26swuw
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#diabetes #endocrinologia

★ Los vídeos de este canal son solo informativos y divulgativos. De ningún modo pretenden sustituir el consejo médico directo. Si tienes o crees tener alguna síntoma, signo o enfermedad descrito en estos vídeos, siempre debes consultar a tu médico de referencia. Nada puede sustituir la relación directa médico-paciente.

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El Dr. Juan F. Ascaso, presidente de la Sociedad Española de la Arteriosclerosis (SEA), participa en en la sesión ‘De las recomendaciones de las guías a la práctica clínica real’, perteneciente a la ‘Jornada Galáctica sobre Guías de Lípidos y objetivos a alcanzar en los pacientes de más alto riesgo cardiovascular’ (Málaga, 4-5 abril, 2014).

Accede a la jornada completa en htt://guiaslipidos.secardiologia.es
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📑 La diabetes mellitus tipo 1 es una diabetes de origen autoinmunitario, (diabetes insulinodependiente) esta sucede por la destrucción de las células beta del páncreas; La diabetes mellitus tipo 2 está más asociada a una descompensación de los lípidos del cuerpo (provocado por la obesidad) y también por la disminución de la captación de la glucosa por parte del organismo.

TED talk sobre diabetes y obesidad:

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📌 REFERENCIAS y BIBLIOGRAFÍA 📚
☑️ Medicina interna. Farreras – Rozman 18va ed. © 2016 Elsevier.
☑️ Porth Fisiopatología. Grossman – Mattson 9na ed. © 2014 Wolters Kluwer.
☑️ Harrison principios de Medicina Interna. 19na ed. © 2015 McGraw-Hill.
☑️ Histología texto y atlas. Wojciech Pawlina 7ma ed. © 2016 Wolters Kluwer
☑️ http://atlas.med.uchile.cl/43.htm (Sobre los Linfocitos AUTORREACTIVOS)
☑️ https://www.drugs.com/health-guide/balanitis.html (SOBRRE LAS INFECCIONES GENITO-URINARIAS)
☑️ https://www.ncbi.nlm.nih.gov/pubmed/28065975 (SOBRRE LAS INFECCIONES GENITO-URINARIAS)
☑️ https://diabetes.diabetesjournals.org/content/35/11/1215 (SOBRE EL HLA)
☑️ https://www.nature.com/articles/35053000 (SOBRE HORMONA RESISTINA)
☑️ https://www.frontiersin.org/articles/10.3389/fendo.2017.00343/full (SOBRE LA DESTRUCCIÓN AUTOINMUNE DEL ISLOTE PANCREATICO)
☑️ Giovannone B, Scaldaferri ML, Federici M et al. Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential. Diabetes Metab Res Rev 2000;16:434-41 (SOBRE LA RESISTENCIA A LA INSULINA)
☑️ http://www.scielo.org.mx/scielo.php?pid=S0016-38132005000600009&script=sci_arttext (SOBRE LAS HORMONAS PRODUCIDAS POR EL TEJIDO ADIPOSO)
☑️ Chen, Zhonge; Yu, Rong; Xiong, Ying; Du, Fangteng; Zhu, Shuishan (octubre de 2017). «A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease» (UN CÍRCULO VICIOSO ENTRE LA RESISTENCIA A LA INSULINA Y LA INFLAMACIÓN EN LA ENFERMEDAD DE HÍGADO GRASO NO ALCOHÓLICO). ENLACE: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644081/
☑️ Gray Anatomía para Estudiantes 2ed. (2010) Elsevier.

#Endocrinología #Medicina #Diabetes

TEMAS EN ESTE VIDEO
0:00 Introducción
2:14 Insulina
6:15 Diabetes TIPO 1
10:02 Diabetes TIPO 2
15:49 Manifestaciones clínicas
23:09 Complicaciones
33:04 Diagnóstico y Tratamiento
37:09 Referencias

Aviso:
El objetivo de este video es introducir y explicar de manera introductoria el contenido de DIABETES MELLITUS, para confirmar y ampliar el conocimiento dirigirse a las fuentes de más arriba.

Algunas imágenes usadas en este video son de propiedad intelectual de sus creadores; para ver su origen ir a las referencias.

Contacto: Mediversia2017@gmail.com
Producido y narrado por: Eslin Cipión Bueno
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Please read and agree to the disclaimer before watching this video.
. Diabetes Mellitus – Mechanism and Causes of Insulin Resistance

Let’s discuss how type 2 diabetes mellitus occurs. We will review the pathology and the mechanism that causes diabetes mellitus. We will build upon these concepts to discuss anti-diabetic lifestyle and drugs in the future.

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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. …
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

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